"Over the years, BIO-CAT has had the good fortune to hire excellent people to run our operation."

- Ed Schuler, BIO-CAT CEO and Founder


The human microbiome and its importance for overall health and well-being have just begun to be explored. Probiotic products are one of the fastest growing segments of the dietary supplement market. Traditional probiotics have been shown to support digestive health, but their effectiveness may be limited by the vulnerability of these organisms to survive adverse storage conditions, such as prolonged storage at high temperature or exposure to moist environments.

Spores forming probiotics have the advantage of surviving the acidic environment in the stomach and germinating in the gastrointestinal tract1.  The germinated cells quickly begin producing a variety of enzymes that assist in breaking down food as well as functioning in a variety of other ways to promote digestive health.

OPTI-BIOME® Bacillus subtilis MB40® is a non-GMO, shelf stable probiotic strain. This strain is naturally protected by its spore coating, which provides resistance to pH and temperature extremes and ensures long term stability. This added feature allows you to skip the microencapsulation process, which is commonly practiced to ensure your product survives and is delivered in the proper location. These features make it an ideal probiotic ingredient for dietary supplements.

OPTI-BIOME® Bacillus subtilis MB40® may be blended with enzymes and/or other dietary supplement ingredients to produce products with a variety of claims.

OPTI-BIOME® Bacillus subtilis MB40®

is self-affirmed GRAS via expert panel review:

  • Highly concentrated – 100 Billion CFU/g
  • Unique strain – Registered with ATCC
  • Shelf stable at room temperature – no refrigeration required
  • Heat and pH resistant – survivability during manufacturing process


Please contact us for more information on how you may be able to bring your probiotic dietary supplement product to market with more activity at a lower production cost, supporting your label without over-formulation.



  1. Casula, et al., “Bacillus Probiotics: Spore Germination in the Gastrointestinal Tract”, Applied and Environmental Microbiology, May 2002, pp. 2344-2352 vol. 68.